期刊论文详细信息
Sao Paulo Medical Journal | |
Impact of predictors upon the reduction of lipid parameters in family medicine practice | |
Yusuf Cetin Doganer1  Kurt Angstman1  James Rohrer1  Stephen Merry1  | |
关键词: Dyslipidemias; Cholesterol LDL; Hydroxymethylglutaryl-CoA reductase inhibitors; Lipids; Family practice; Dislipidemias; LDL-Colesterol; Inibidores de hidroximetilglutaril-CoA redutases; Lipídeos; Medicina de Família e Comunidade; | |
DOI : 10.1590/1516-3180.2014.00321501 | |
来源: SciELO | |
【 摘 要 】
ABSTRACTCONTEXT AND OBJECTIVE:To evaluate predictors of changes in lipid parameters consisting of LDL-C (low-density lipoprotein cholesterol), TC (total cholesterol) and non-HDL-C (non-high density lipoprotein cholesterol) among primary care patients.DESIGN AND SETTING:Retrospective study conducted on family medicine patients.METHODS:Demographic features and other clinically relevant information were abstracted from medical records. The primary outcome was the difference in LDL-C level from initial testing to the index test. Secondary outcomes were the changes in TC and non-HDL-C levels between two measurements.RESULTS:Three hundred and eleven participants were included in the final secondary analysis. Multiple linear regression revealed that male patients (β = 4.97, P = 0.040), diabetes (β = 9.75, P = 0.003) and higher LDL-C levels at baseline (β = 0.35, P < 0.001) were positively associated with LDL variance, whereas longer time period (β = -0.15, P = 0.045) and familial hypercholesterolemia history (β = -7.56, P = 0.033) were negatively associated. Male patients (β = 8.45, P = 0.002), DM (β = 9.26, P = 0.011), higher TC levels at baseline (β = 0.35, P < 0.001) and taking statins (β = 7.31, P = 0.023) were positively associated with TC variance, whilst longer time period (β = -0.183, P = 0.031) and familial hypercholesterolemia (β = -10.70, P = 0.008) were negatively associated.CONCLUSION:In the present study, patients who were male, on statin treatment, diagnosed with diabetes and had higher baseline lipid values were more likely associated with better lipid outcomes at future testing.【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
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