Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in Rats

Materials Research

Marcelo Rodrigues Da Cunha¹  Fernanda Araujo Menezes¹  Geovane Ribeiro Dos Santos¹  Clóvis Antônio Lopes Pinto¹  Benedito Barraviera¹  Virginia Da Conceição Amaro Martins¹  Ana Maria De Guzzi Plepis¹  Rui Seabra Ferreira Junior¹ 

关键词: bioceramic;    fibrin sealant;    bone regeneration;   

DOI  :  10.1590/1516-1439.316014

来源: SciELO

【 摘 要 】

Biomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of bone and fibrin sealants due to their hemostatic properties. The objective was to evaluate the repair of cranial defects in 40 rats, grafted with hydroxyapatite and a new fibrin sealant derived from snake venom. The animals were divided into four groups: C (control, no graft); Ha (hydroxyapatite); FS (fibrin sealant), and HaFS (hydroxyapatite and fibrin sealant). The animals were euthanized 2 and 6 weeks after surgery and wound area were submitted to analysis. After 2 weeks, immature bone was formed from the borders of the defect and in groups Ha and HaFS, few hydroxyapatite particles were surrounded by new bone. After 6 weeks, the new bone was mature and surrounded several hydroxyapatite particles, without connective tissue interposition and the volume of new bone was higher in HaFS group. The hydroxyapatite in combination with the new fibrin sealant accelerates bone repair.

【 授权许可】

CC BY   
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