Appetite-related hormone levels in obese women with and without binge eating behavior

Revista de Nutrição

Paula Paraguassú Brandão²  Érica Patrícia Garcia-souza²  Fabiana Alves Neves²  Mário José Dos Santos Pereira²  Rosely Sichieri¹  Aníbal Sanchez Moura² 

[1],Universidade do Estado do Rio de Janeiro Instituto de Biologia Departamento de Ciências FisiológicasRio de Janeiro RJ ,Brasil

关键词: Ghrelin;    Insulin;    Obesity;    PYY 3-36;    Binge-eating disorder;    Grelina;    Insulina;    Obesidade;    PYY 3-36;    Transtorno de compulsão alimentar;   

DOI  :  10.1590/S1415-52732011000500001

来源: SciELO

【 摘 要 】

OBJECTIVE: The aim of this study was to evaluate serum levels of appetite-related hormones (peptide YY3-36, total ghrelin, leptin and insulin) before and after consumption of a meal in obese women with and without binge eating episodes and normal weight women. METHODS: Twenty-five women aged 32-50 years were invited to participate in this study, including 9 normal weight women without binge eating episodes (20-25kg/m², group 1), 9 obese women with binge eating episodes (³30kg/m², group 2), and 7 obese women without binge eating episodes (group 3). Four blood samples were collected from each participant, one being 60 minutes before and three being 15, 45 and 90 minutes after a meal. The composition of the meal was 55% carbohydrates, 15% protein and 30% lipids. RESULTS: Group 3 presented increased HOMA-IR (M=2.5, SD=1.04) when compared with group 1 (M=1.5, SD=0.53) and group 2 (M=1.8, SD=0.58), p=0.04. Body mass index (p<0.0001), leptin (p<0.0001) and insulin (p=0.01) were higher in group 3 than in the other groups before and after the meal. Additionally, total ghrelin (p=0.003) and PYY3-36 (p=0.02) levels were lower in group 2 than in the other groups before and after the meal. After adjustment for body mass index, only the lower PYY3-36 level of group 2 remained statistically different from the other groups (p=0.01). CONCLUSION: Our study suggests that lower levels of PYY 3-36 are associated with binge eating in obese women.

【 授权许可】

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