Determination of the regulatory properties of Yucca schidigera extracts on the biochemical parameters and plasma hormone levels associated with obesity

Revista Brasileira de Farmacognosia

Eryavuz, Abdullah¹  Karabag, Funda¹  Usak University, Uşak, Turkey¹  Afyon Kocatepe University, Afyonkarahisar, Turkey¹  Akkol, Esra Küpeli¹  Ince, Sinan¹  Kucukkurt, Ismail¹  Sözbilir, Nalan Bayşu¹  Gazi University, Ankara, Turkey¹  Süntar, Ipek¹ 

关键词:  Adiponectin;    Ghrelin;    Insulin;    Leptin;    Obesity;    Mice;   

DOI  :  10.1016/j.bjp.2015.12.005

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Yucca schidigera Ortgies, Asparagaceae, is a herbaceous plant. Due to the high saponin content the powdered branches and leaves are used as natural food additive for human and animal. The aim of this study was to investigate the effects of Y. schidigera extracts on plasma leptin, ghrelin, adiponectin, insulin, thyroid hormones and some biochemical parameters in mice fed a high-fat diet. Male Swiss Albino mice were divided into seven equal groups. Group I (negative control group) was given standard diet; Group II was given high-fat diet; Group III was given high-fat diet with carboxymethylcellulose; Groups IV–VII were given hexane, petroleum ether, ethyl acetate, and methanol extracts of Y. schidigera and high-fat diet via gastric gavage for 60 days. High-fat diet significantly increased plasma leptin, insulin, free T3 hormone, glucose, cholesterol, low-density lipoprotein, triacylglyceride, aspartate aminotransferase and alanine aminotransferase levels, and significantly decreased plasma ghrelin, adiponectin and free T4 hormone levels. On the other hand, hormone levels, lipid profile and biochemical parameters were improved by the administration of the PE extract. Y. schidigera extracts could be used as preventive medicine in nutritional disorders via regulating energy metabolism and hormonal functions.

【 授权许可】

Unknown