Association between the g.296596G > A genetic variant of RELN gene and susceptibility to autism in a Chinese Han population

Genetics and Molecular Biology

Xiaoyan Fu¹  Zhu Mei¹  Lixin Sun¹ 

[1] ,Tongji University Department of Pediatrics Shanghai,China

关键词: autism;    susceptibility;    association analysis;    RELN gene;    genetic variants;   

DOI  :  10.1590/S1415-47572013005000037

来源: SciELO

【 摘 要 】

Autism is a childhood neuro-developmental disorder, and Reelin (RELN) is an important candidate gene for influencing autism. This study aimed at investigating the influence of genetic variants of the RELN gene on autism susceptibility. In this study, 205 autism patients and 210 healthy controls were recruited and the genetic variants of the RELN gene were genotyped by the created restriction site-polymerase chain reaction (CRS-PCR) method. The influence of genetic variants on autism susceptibility was analyzed by association analysis, and the g.296596G > A genetic variant in exon10 of the RELN gene was detected. The frequencies of allele/genotype in autistic patients were significantly different from those in healthy controls, and a statistically significant association was detected between this genetic variant and autism susceptibility. Our data lead to the inference that the g.296596G > A genetic variant in the RELN gene has a potential influence on autism susceptibility in the Chinese Han population.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License