Genetics and Molecular Biology | |
Myeloproliferative syndrome of monosomy 7: a brief report | |
Terezinha De Jesus Marques-salles2  Eliane Maria Soares-ventura2  Nathalia Lopes De Oliveira2  Mariluze Silva2  Reijane Assis1  Vera Lúcia Lins De Morais2  Luize Otero1  Teresa Fernandez1  Maria Do Socorro Pombo-de-oliveira1  Maria Tereza Cartaxo Muniz2  Neide Santos1  | |
[1] ,Universidade de Pernambuco Hospital Universitário Oswaldo Cruz Centro de Oncohematologia PediátricaRecife PE ,Brazil | |
关键词: leukemia; monosomy 7; myeloproliferative syndrome; | |
DOI : 10.1590/S1415-47572008000100007 | |
来源: SciELO | |
【 摘 要 】
We report the case of a five-month-old black male infant who had recurrent episodes of respiratory infections and also presented anemia and enlargements of the spleen, liver and lymphnodes. Hematological analysis revealed morphological abnormalities with megaloblastic dyserythropoiesis, while fetal hemoglobin assaying showed normal levels. Conventional and molecular cytogenetic analysis revealed monosomy of chromosome 7. Despite all therapeutic efforts during allogenic bone marrow transplantation, the child died due to generalized infection. The clinical and genetic distinctions between monosomy 7 syndrome and myelodysplastic disorders in childhood are discussed.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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