Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: report of a new case and review of the literature

Genetics and Molecular Biology

Luize Otero¹  Daiane Correa De Souza¹  Rita De Cássia Tavares¹  Bernadete Evangelho Gomes¹  Telma França Padilha¹  Luiz Fernando Bouzas¹  Teresa De Souza Fernandez¹  Eliana Abdelhay¹ 

[1],Instituto Nacional de Câncer Centro de Transplante de Medula Óssea Rio de Janeiro RJ ,Brazil

关键词: monosomy 7;    donor cell leukemia;    bone marrow transplantation;    severe aplastic anemia;   

DOI  :  10.1590/S1415-47572012005000056

来源: SciELO

【 摘 要 】

Monosomy 7 arises as a recurrent chromosome aberration in donor cell leukemia after hematopoietic stem cell transplantation. We report a new case of donor cell leukemia with monosomy 7 following HLA-identical allogenic bone marrow transplantation for severe aplastic anemia (SAA). The male patient received a bone marrow graft from his sister, and monosomy 7 was detected only in the XX donor cells, 34 months after transplantation. The patient's bone marrow microenvironment may have played a role in the leukemic transformation of the donor hematopoietic cells.

【 授权许可】

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