RUNX1: A MicroRNA Hub in Normal and Malignant Hematopoiesis

International Journal of Molecular Sciences

Stefano Rossetti¹ 

[1] Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA; E-Mail

关键词: RUNX1 (AML1);    microRNAs (miRNAs);    hematopoiesis;    leukemia;    transcription factor-microRNA circuits;    gene regulatory networks;   

DOI  :  10.3390/ijms14011566

来源: mdpi

【 摘 要 】

Hematopoietic development is orchestrated by gene regulatory networks that progressively induce lineage-specific transcriptional programs. To guarantee the appropriate level of complexity, flexibility, and robustness, these networks rely on transcriptional and post-transcriptional circuits involving both transcription factors (TFs) and microRNAs (miRNAs). The focus of this review is on RUNX1 (AML1), a master hematopoietic transcription factor which is at the center of miRNA circuits necessary for both embryonic and post-natal hematopoiesis. Interference with components of these circuits can perturb RUNX1-controlled coding and non-coding transcriptional programs in leukemia.

【 授权许可】

CC BY   
© 2013 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.