Splenectomy prior to antiviral therapy in patients with hepatitis C virus related decompensated cirrhosis

Brazilian Journal of Infectious Diseases

Ji Fanpu²  Shu Zhang²  Na Huang¹  Hong Deng¹  Zongfang Li² 

[1] ,Xi'an Jiaotong University College of Medicine Department of Hepatology and Surgery Shaanxi Province ,China

关键词: Hepatitis C virus;    Thrombocytopenia;    Splenectomy;    Antiviral therapy;   

DOI  :  10.1016/j.bjid.2013.02.004

来源: SciELO

【 摘 要 】

Patients with hepatitis C virus-related decompensated cirrhosis can benefit frominterferonbased antiviral therapy, but the common complication of cytopenia is a contraindication for this treatment. Splenectomy prior to interferon therapy may alleviate this problem. To investigate whether splenectomy improves the efficacy of antiviral therapy, 13 interferonnaïve hepatitis C virus decompensated cirrhotic patients underwent splenectomy between January 2008 and January 2011, followed 1-3 months later by an interferon-based therapeutic regimen (pegylated/standard interferon-α combined with ribavirin for 48 weeks). Ten (76.9%) of the patients developed postoperative complications, which included minor portal vein thrombosis (2/13, 15.4%) and transient ascites (8/13, 61.5%). At one-month postsplenectomy, the patients showed significantly increased platelet (pre-surgery: 48.2 ± 15.9 vs. 186.0 ± 70.6×10 µL-1, p < 0.001) and leukocyte (2.1 ± 0.5 vs. 5.7 ± 1.4 × 10³ µL-1, I < 0.001) counts. Eight (61.5%) of the patients achieved sustained virological response, including all HCV genotype 2a-infected patients (4/4, 100%) and some of the genotype 1b-infected patients (4/9, 44.4%). Temporary interferon-α suspension was required for one patient to address severe intestinal infection. These results indicate that splenectomy prior to interferon-based therapy was safe and may facilitate adherence to subsequent antiviral therapy in selected HCV cirrhotic patients with portal hypertension and hypersplenism.

【 授权许可】

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