Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy

Brazilian Journal of Infectious Diseases

Vicente Sperb Antonello²  Marcelo Campos Appel-da-silva¹  Dimas Alexandre Kliemann¹  Breno Riegel Santos¹  Cristiane Valle Tovo¹ 

[1] ,Hospital Fêmina Department of Infection Control Porto Alegre RS ,Brazil

关键词: HIV;    Hepatitis C;    Coinfection;    HAART;    CD4;    Immunological response;   

DOI  :  10.1016/j.bjid.2013.01.015

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients. METHODS: The study enrolled 65 human immunodeficiency virus-1-infected subjects who initiated highly active antiretroviral therapy and attended follow-up visits over 48 weeks from 2008 to 2010. They were grouped based on hepatitis C virus-RNA results. Virological and immunological responses were monitored at baseline and at the end of weeks 12, 24, 36, and 48. RESULTS: There were 35 human immunodeficiency virus monoinfected and 30 human immunodeficiency virus/hepatitis C virus coinfected patients. In the present study human immunodeficiency virus/hepatitis C virus coinfection did not seem to influence CD4 Tlymphocytes recovery. There was no difference between the curves of CD4 T-lymphocytes raise of coinfected and monoinfected groups. CONCLUSION: This prospective study confirms that hepatitis C virus infection does not seem to be associated with impaired CD4 T-lymphocytes recovery after HAART.

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