Clinical laboratory assessment of hepatitis C and HIV coinfected patients according to the antiretroviral therapy received

Revista do Instituto de Medicina Tropical de São Paulo

Roberto M. Carrasco Navarro¹  Maria Cássia Jacintho Mendes-correa¹  Norma De Paula Cavalheiro¹  Antonio Alci Barone¹ 

[1] ,Instituto de Medicina Tropical de São Paulo Laboratório de Hepatites São Paulo SP ,Brazil

关键词: Coinfection;    HIV;    HCV;    AIDS;    HAART;    Liver biopsy;   

DOI  :  10.1590/S0036-46652005000100003

来源: SciELO

【 摘 要 】

During the year of 2001, a retrospective, descriptive study in order to determine the influence of the antiretroviral therapy received by 111 HIV-HCV coinfected patients who had undergone at least one liver biopsy was conduced, 74 of them were treated with a protease inhibitor regimen (WPI), and 37 with a non-protease inhibitor regimen (NPI). The main characteristics found were: a young patient population (mean age 41 years old in both groups), composed in most part of male individuals (74.3% WPI and 51.4% NPI) with previous risk factors for both infections (WPI 93.2% and NPI 89.2%). The most significant findings included AIDS-defining disease (WPI 18.9% and NPI 13.5% of the cases), elevated hepatic enzyme levels (WPI: SGOT 52.1 and NPI 53.2), absence of liver disease-related symptoms (16.2% for both groups), average CD4 count > 350 for both groups (WPI 362.2 and NPI 378.1), predominantly low-grade fibrosis in both populations (0-2 in 63.6% of WPI patients and in 80% of NPI patients), with necro-inflammatory activity ranging from 5-7 in 51.3% and 42.9% of WPI patients and NPI patients, respectively. It is suggested a sequential biopsy to better evaluate the evolution of the hepatic disease, according to the HAART regimen received.

【 授权许可】

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