Molecular characterization of viruses associated with gastrointestinal infection in HIV-positive patients

Brazilian Journal of Infectious Diseases

Raquel C Silva¹  Fabrício J Benati¹  Giselle Pa Pena¹  Norma Santos¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Microbiologia Department of Virology,Brazil

关键词: HIV infection;    gastrointestinal disorders;    cytomegalovirus;    human bocavirus;   

DOI  :  10.1590/S1413-86702010000600001

来源: SciELO

【 摘 要 】

BACKGROUND: Diarrhea is a major cause of morbidity and mortality among HIV-infected patients worldwide. OBJECTIVE: We sought to determine the frequency of viral gastrointestinal infections among Brazilian HIV-infected patients with diarrhea. METHODS: A collection of 90 fecal specimens from HIV-infected individuals with diarrhea, previously tested for the presence of bacteria and parasite was analyzed by polymerase chain reaction and sequence analysis for the presence of enteric viruses such as astrovirus, norovirus, rotavirus groups A, B and C, adenovirus, herpes simplex virus, Epstein-Barr virus, cytomegalovirus, and human bocavirus. RESULTS: Twenty patients (22.2%; n = 90) were infected with parasites (11 single infections and nine coinfected with virus). Enteropathogenic bacteria were not found. Virus infections were detected in 28.9% (26/90) of the specimens. Cytomegalovirus was the most common virus detected (24.4%; 22/90). Coinfections with viruses and/or parasite were observed in 10 (11.1%) samples. CONCLUSION: Gastrointestinal virus infections were more frequent than parasitic or bacterial infections in this patient population.

【 授权许可】

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