Evaluation of oxidative status in patients with brucellosis

Brazilian Journal of Infectious Diseases

Kivanc Serefhanoglu²  Abdullah Taskin¹  Hale Turan²  Funda Ergin Timurkaynak²  Hande Arslan²  Ozcan Erel¹ 

[1] ,Baskent University Medical Faculty Department of Infectious Diseases and Clinical MicrobiologyAnkara,Turkey

关键词: Brucellosis;    oxidants;    antioxidants;    oxidative stress;   

DOI  :  10.1590/S1413-86702009000400001

来源: SciELO

【 摘 要 】

Oxidative stress can be defined as an increase in oxidants and/or a decrease in antioxidant capacity. We aimed to determine total antioxidant capacity (TAC), total peroxide, malondialdehyde and catalase levels in plasma samples, and calculation of oxidative stress index (OSI) in patients with brucellosis to evaluate their oxidative status using a novel automated method. Sixty-nine patients with brucellosis and 69 healthy control subjects were included in the present study. Plasma levels of total peroxide and malondialdehyde were significantly increased in patients as compared with healthy controls (p<0.001 and p<0.001, respectively). In contrast, TAC level was significantly lower in patients as compared with controls (p<0.001). There was no statistically significant difference between the catalase results of the two groups (p>0.05). OSI level was significantly increased in patients as compared with healthy controls (p<0.001). In conclusion, oxidants were increased and antioxidants were decreased in patients with brucellosis. Oxidative stress was increased in patients with brucellosis.

【 授权许可】

CC BY-NC-ND   
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