期刊论文详细信息
Ciência & Saúde Coletiva | |
From degeneration to infection/inflammation, and from individual-centered to ecologic approaches to investigation of evolving patterns of diseases occurrences in populations | |
Maria Inês Reinert Azambuja1  | |
[1],Universidade Federal do Rio Grande do Sul Faculdade de Medicina Porto Alegre RS ,Brasil | |
关键词: Influenza; Heart disease; Epidemic; Mortality; Ecologic studies; Influenza; Doença cardiovascular; Epidemia; Mortalidade; Ecologia humana; | |
DOI : 10.1590/S1413-81232004000400007 | |
来源: SciELO | |
【 摘 要 】
Variation in attributes of CHD cases over time suggests a temporal change in the source sub-population of cases. It is proposed that an early 20th century expansion of a CHD-prone sub-population, characterized by high-serum cholesterol phenotype and high case-fatality - and which contributed with most of the CHD cases and deaths during the 1960s - may have followed the 1918 Influenza Pandemic. The extinction of those birth-cohorts would have resulted in a relative increase in cases coming from a second source sub-population, characterized by insulin resistance and chronic expression of low grade inflammation markers, comparatively less vulnerable to acutely die from CHD. This re-interpretation of the CHD trend, and the abandonment of the idea of degeneration for inflammation/infection calls for a change in epidemiology. Besides exposures (diet, infection...), temporal variations in proportional representations of inherited and acquired phenotypes associated with individual resistance/vulnerability, would be important determinants of evolving patterns of diseases occurrences in populations.【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202005130139957ZK.pdf | 45KB | download |