Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma

Anais Brasileiros de Dermatologia

Fernanda Guedes Lavorato¹  Maria De Fátima Guimarães Scotelaro Alves¹  Juan Manuel Piñeiro Maceira¹  Natasha Unterstell¹  Laura Araújo Serpa¹  Luna Azulay-abulafia¹ 

关键词: Amyloidosis;    Cutis laxa;    Mucinoses;    Multiple myeloma;    Amiloidose;    Cútis laxa;    Mieloma múltiplo;    Mucinoses;   

DOI  :  10.1590/abd1806-4841.20132531

来源: SciELO

【 摘 要 】

A 57-year-old woman presented with periorbital ecchymoses, laxity in skin folds, polyneuropathy and bilateral carpal tunnel syndrome. A skin biopsy of the axillary lesion demonstrated fragmentation of elastic fibers, but with a negative von Kossa stain, consistent with cutis laxa. The diagnosis of primary systemic amyloidosis was made by the presence of amyloid material in the eyelid using histopathological techniques, besides this, the patient was also diagnosed with purpura, polyneuropathy, bilateral carpal tunnel syndrome and monoclonal gammopathy. She was diagnosed as suffering from multiple myeloma based on the finding of 40% plasma cells in the bone marrow, component M in the urine and anemia. The patient developed blisters with a clear content, confirmed as mucinosis by the histopathological exam. The final diagnoses were: primary systemic amyloidosis, acquired cutis laxa and mucinosis, all related to multiple myeloma.

【 授权许可】

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