Revista da Associação Médica Brasileira | |
Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil | |
Monique Nervo2  Adriano Lubini2  Fabiana Viegas Raimundo1  Gustavo Adolpho Moreira Faulhaber2  Carine Leite2  Leonardo Moura Fischer2  Tania Weber Furlanetto2  | |
[1] ,Hospital de Clínicas de Porto Alegre Internal Medicine Service Porto Alegre RS | |
关键词: Diabetes mellitus; vitamin B 12; metformin; Diabetes mellitus; vitamina B 12; metformina; | |
DOI : 10.1590/S0104-42302011000100015 | |
来源: SciELO | |
【 摘 要 】
OBJECTIVE: The objective of this study was to evaluate the presence of vitamin B12 deficiency and the factors associated with serum vitamin B12 levels in a sample of metformin-treated Brazilian diabetic patients. METHOD: Cross-sectional study. RESULTS: 144 patients were included. Serum vitamin B12 levels were low (< 125 pmol/L) in 10 patients (6.9%) and possibly low (125 - 250 pmol/L) in 53 patients (36.8%). Serum vitamin B12 levels were negatively associated with age (B = -3.17; β= -0.171; p = 0.037) and duration of metformin use (B= -33.36; β= -0.161; p = 0.048), and positively associated with the estimated intake of vitamin B12 (B= 67.96; β= 0.249; p = 0.002). CONCLUSION: The present findings suggest a high prevalence of vitamin B12 deficiency in metformin-treated diabetic patients. Older patients, patients in long term treatment with metformin and low vitamin B12 intake are probably more prone to this deficiency.
【 授权许可】
CC BY-NC
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