Vitamin B12 in metformin-treated diabetic patients: a cross-sectional study in Brazil

Revista da Associação Médica Brasileira

Monique Nervo²  Adriano Lubini²  Fabiana Viegas Raimundo¹  Gustavo Adolpho Moreira Faulhaber²  Carine Leite²  Leonardo Moura Fischer²  Tania Weber Furlanetto² 

[1] ,Hospital de Clínicas de Porto Alegre Internal Medicine Service Porto Alegre RS

关键词: Diabetes mellitus;    vitamin B 12;    metformin;    Diabetes mellitus;    vitamina B 12;    metformina;   

DOI  :  10.1590/S0104-42302011000100015

来源: SciELO

【 摘 要 】

OBJECTIVE: The objective of this study was to evaluate the presence of vitamin B12 deficiency and the factors associated with serum vitamin B12 levels in a sample of metformin-treated Brazilian diabetic patients. METHOD: Cross-sectional study. RESULTS: 144 patients were included. Serum vitamin B12 levels were low (< 125 pmol/L) in 10 patients (6.9%) and possibly low (125 - 250 pmol/L) in 53 patients (36.8%). Serum vitamin B12 levels were negatively associated with age (B = -3.17; β= -0.171; p = 0.037) and duration of metformin use (B= -33.36; β= -0.161; p = 0.048), and positively associated with the estimated intake of vitamin B12 (B= 67.96; β= 0.249; p = 0.002). CONCLUSION: The present findings suggest a high prevalence of vitamin B12 deficiency in metformin-treated diabetic patients. Older patients, patients in long term treatment with metformin and low vitamin B12 intake are probably more prone to this deficiency.

【 授权许可】

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