Long-term thalidomide use in refractory cutaneous lesions of systemic lupus erythematosus

Revista da Associação Médica Brasileira

E. I. Sato¹  L. S. S. Assis¹  V. P. Lourenzi¹  L. E. C. Andrade¹ 

[1] ,Universidade Federal de São Paulo Escola Paulista de Medicina Division of Rheumatology SP ,Brazil

关键词: Thalidomide;    Systemic lupus erythematosus;    Cutaneous lesions;    Treatment;    Talidomida;    Lúpus eritematoso sistêmico;    Lesões cutâneas;    Tratamento;   

DOI  :  10.1590/S0104-42301998000400007

来源: SciELO

【 摘 要 】

OBJECTIVE: To evaluate the efficacy of long-term thalidomide treatment in cutaneous lesions of systemic lupus erythematosus (SLE), not responsive to conventional therapy. PATIENTS AND METHODS: Were selected 18 SLE patients (ACR criteria) with active cutaneous lesions not responsive to chloroquine, photoprotectors and low doses prednisone and who presented good response to thalidomide but relapsed after withdrawal of the drug. All female patients had no risk of pregnancy. Thalidomide was reintroduced and maintained at low dose (25-100mg/day) for a minimum of 6 months. RESULTS: Eighteen patients (16 females) with mean age of 34.2yo (16-57y.o.) received thalidomide for 6-21 months (mean 8.5m). The mean dose of prednisone at beginning of study was 38.3 mg/d and at the end was 9.7mg/d (p<0.05). Complete remission of cutaneous lesions was observed in thirteen patients (72%) and partial remission in five (28%). Side effects observed were: drowsiness in eight patients, intestinal constipation in 5, transient oliguria in 1, paresthesia of hand with normal electromyography in another one. All side effects disappeared with reduction of thalidomide dose and no patient needed to stop treatment owing to side effect. CONCLUSION: Thalidomide is a good alternative therapy to SLE patients with refractory cutaneous lesions and without any risk of pregnancy.

【 授权许可】

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