P53 gene: major mutations in neoplasias and anticancer gene therapy

Ciência Rural

Caroline Rocha De Oliveira Lima²  Rogério Elias Rabelo¹  Valcinir Aloísio Scalla Vulcani¹  Lorena Damasio Cardoso¹  Nicaelle Luan De Moura Sousa¹  Veridiana Maria Brianezi Dignani De Moura¹ 

[1] ,Universidade Federal de Goiás (UFG) Escola de Veterinária e Zootecnia (EVZ) Goiânia GO ,Brasil

关键词: mutations;    neoplasia;    gene therapy;    p53;    mutações;    neoplasia;    geneterapia;    p53;   

DOI  :  10.1590/S0103-84782012000500014

来源: SciELO

【 摘 要 】

The p53 gene encodes a protein that has molecular weight of 53kD and is also called p53 protein, being constantly studied for its classic concept of "genome guardian". This gene plays a range of essential functions to ensure the cell cycle control, in addition to playing a central role in carcinogenesis. With respect to neoplasias, it prevents the neoplastic transformation through three intricate mechanisms. Depending on the extent of the mutation, different responses may be sent by p53 and those range since the disruption of the cell cycle, the correction of the mutation through the activation of repair proteins or still, the induction of senescence or cell death by apoptosis. This review aims to address the structural and functional aspects of the p53 gene and protein, and also reaffirm their participation in the carcinogenesis control, approaching their major mutations and the anticancer gene therapy involving this gene.

【 授权许可】

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