Etiologic factors associated with oral squamous cell carcinoma in non-smokers and non-alcoholic drinkers: a brief approach

Brazilian Dental Journal

Fabiana Vargas-ferreira¹  Fernanda Nedel²  Adriana Etges²  Ana Paula Neutzling Gomes²  Cristiane Furuse²  Sandra Beatriz Chaves Tarquinio² 

[1] ,Federal University of Pelotas Departament of Social Medicine Pelotas RS ,Brazil

关键词: epidemiology;    oral squamous cell carcinoma;    human papillomavirus;   

DOI  :  10.1590/S0103-64402012000500020

来源: SciELO

【 摘 要 】

Oral squamous cell carcinoma (OSCC) is the fifth most common type of cancer in the world. The effect of some etiological factors is well established in the literature, such as consumption of tobacco and alcohol. However, approximately 15 to 20% of all oral cancer cases occur in patients without the traditional risk factors, reflecting in numerous cases of OSCC in non-smokers and non-alcoholic drinkers. Also, several studies have suggested a possible association between human papillomavirus and OSCC. Under these aspects, the purpose of this study is to address cases of oral cancer in non-smokers and non-drinkers focusing on the role of HPV, thus contributing to improve the diagnosis and monitoring of OSCC. A computer database search was performed using the Pubmed database. The search key words were: epidemiology, oral squamous cell carcinoma, risk factors and human papillomavirus. It is important to assess patients without the potential risk factors, since this knowledge may help identifying other features associated with the occurrence of oral cancer, enabling an appropriate clinical management and monitoring.

【 授权许可】

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