Influence of serum and necrotic soft tissue on the antimicrobial effects of intracanal medicaments

Brazilian Dental Journal

Julio C. Machado De Oliveira¹  Flávio R. F. Alves¹  Milton De Uzeda¹  Isabela N. Rôças¹  José F. Siqueira Jr.¹ 

[1] ,Estácio de Sá University Dental School Department of EndodonticsRio de Janeiro RJ ,Brazil

关键词: Enterococcus faecalis;    Candida albicans;    intracanal medication;    antimicrobial activity;    serum;    organic matter;   

DOI  :  10.1590/S0103-64402010000400001

来源: SciELO

【 摘 要 】

The purpose of this study was to investigate the influence of serum and necrotic soft tissue on the antimicrobial activity of intracanal medicaments. The medicaments tested were: calcium hydroxyde/glycerin paste, calcium hydroxide/chlorhexidine paste, calcium hydroxide/camphorated paramonochlorophenol/glycerin paste, and chlorhexidine/zinc oxide paste. Survival of Enterococcus faecalis and Candida albicans exposed to the medicaments tested in the presence or absence of serum or necrotic tissue was monitored in three in vitro experiments where samples for culturing were taken at different time periods. The overall results demonstrated that the antimicrobial activity of all intracanal medicaments tested was slowed down in the presence of necrotic tissue. Calcium hydroxide pastes in glycerin or chlorhexidine were significantly affected by serum. Of the medicaments tested in this study, the least affected was the calcium hydroxide/camphorated paramonochlorophenol/glycerin paste.

【 授权许可】

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