Efficacy of low-level laser therapy and aluminum hydroxide in patients with chemotherapy and radiotherapy-induced oral mucositis

Brazilian Dental Journal

Aline Gouvêa De Lima²  Reynaldo Antequera²  Maria Paula Siqueira De Melo Peres²  Igor Moysés Longo Snitcosky¹  Miriam Hatsue Honda Federico¹  Rosângela Correa Villar¹ 

[1] ,University of São Paulo Medical School Clinics HospitalSão Paulo SP ,Brazil

关键词: lasers;    aluminum hydroxide;    stomatitis;    radiotherapy;    head and neck cancer;   

DOI  :  10.1590/S0103-64402010000300002

来源: SciELO

【 摘 要 】

This study evaluated the efficacy of low-level laser therapy (LLLT) and aluminum hydroxide (AH) in the prevention of oral mucositis (OM). A prospective, comparative and non-randomized study was conducted with 25 patients with head and neck cancer subjected to radiotherapy (RT) or radiochemotherapy (RCT). Twelve patients received LLLT (830 nm, 15 mW, 12 J/cm²) daily from the 1st day until the end of RT before each sessions during 5 consecutive days, and the other 13 patients received AH 310 mg/5 mL, 4 times/day, also throughout the duration of RT, including weekends. OM was measured using an oral toxicity scale (OTS) and pain was measured using the visual analogue scale (VAS). EORTC questionnaires were administered to the evaluate impact of OM on quality of life. The LLLT group showed lower mean OTS and VAS scores during the course of RT. A significant difference was observed in pain evaluation in the 13th RT session (p=0.036). In both groups, no interruption of RT was needed. The prophylactic use of both treatments proposed in this study seems to reduce the incidence of severe OM lesions. However, the LLLT was more effective in delaying the appearance of severe OM.

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