Virginicin, a New Naphthalene from Kosteletzkya virginica (Malvaceae)

Journal of the Brazilian Chemical Society

Bai Bai¹  Xu-wei Gu¹  Yu Chen¹  Fu-qin Guan¹  Yu Shan¹  Xu Feng¹ 

关键词: naphthalene;    Kosteletzkya virginica;    DPPH•;    nitric oxide;    cytotoxic activity;   

DOI  :  10.5935/0103-5053.20150032

来源: SciELO

【 摘 要 】

A new naphthalene, 8-methoxy-2,7-dihydroxyl-4-(1'-hydroxyl-isopropyl)-6-methyl-1-naphthaldehyde, together with twelve known compounds were isolated from the tubers of Kosteletzkya virginica. Their structures were elucidated by spectroscopic methods, including 1D-, 2D-nuclear magnetic resonance (NMR) and high-resolution time of flight electrospray ionization mass spectrometry (HRTOFESIMS). Some compounds were evaluated for their potential in scavenging diphenyl-picryl hydrazyl radical (DPPH•), inhibition of nitric oxide (NO) induced by lipopolysaccharide (LPS), and cytotoxic activity. The new compound showed activities against DPPH•, NO, human acute promyelocytic leukemia (HL-60) and human colorectal adenocarcinoma (LOVO), with IC50 of 34.6, 12.5, 40.5, 31.7 μmol L-1 respectively.

【 授权许可】

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