Potential Insecticidal Activity of Steroidal C-17 Pyrazolinyl Derivatives

Journal of the Brazilian Chemical Society

Ning-juan Fan¹  Jin-ming Gao¹  Jiang-jiang Tang¹ 

关键词: steroid;    progesterone;    pyrazoline;    insecticidal activity;   

DOI  :  10.5935/0103-5053.20140248

来源: SciELO

【 摘 要 】

Agrochemical research, over the last two decades, has resulted in the discovery of chemically novel insecticides, of which steroids-based compounds that mimic the action of hormones have been considered as safe insecticides. In this study, eight steroidal C-17 pyrazolinyl derivatives were resynthesized through molecular hybridization and their insecticidal activities against 4thinstar larvae of Mythimna separate were evaluated. These results showed that some compounds exhibited significant insecticidal activities and the susceptibility assays were expressed as the median lethal dose (LD50), of which one of the compounds exerted the most potent insecticidal activity (LD50 = 296 µg g-1), comparable to that of the natural product insecticide, celangulatin V (LD50 = 260 µg g-1). This strategy led to a promising candidate for the development of new steroidal insecticidal agents.

【 授权许可】

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