Key to Life: Physiological Role and Clinical Implications of Progesterone

International Journal of Molecular Sciences

Bernadett Nagy¹  József Bódis¹  Viola Vértes¹  Júlia Szekeres-Barthó¹  Endre Sulyok¹  Bálint Farkas¹  Gábor L. Kovács¹  Ákos Várnagy¹  Kálmán Kovács¹ 

[1] National Laboratory for Human Reproduction, University of Pécs, 7624 Pécs, Hungary;

关键词: progesterone;    progestogens;    progestins;    steroid;    in vitro fertilization (IVF);    intracytoplasmic sperm injection (ICSI);   

DOI  :  10.3390/ijms222011039

来源: DOAJ

【 摘 要 】

The most recent studies of progesterone research provide remarkable insights into the physiological role and clinical importance of this hormone. Although the name progesterone itself means “promoting gestation”, this steroid hormone is far more than a gestational agent. Progesterone is recognized as a key physiological component of not only the menstrual cycle and pregnancy but also as an essential steroidogenic precursor of other gonadal and non-gonadal hormones such as aldosterone, cortisol, estradiol, and testosterone. Based on current findings, progesterone and novel progesterone-based drugs have many important functions, including contraception, treatment of dysfunctional uterine bleeding, immune response, and prevention of cancer. Considering the above, reproduction and life are not possible without progesterone; thus, a better understanding of this essential molecule could enable safe and effective use of this hormone in many clinical conditions.

【 授权许可】

Unknown