Synthesis and Anti-Bacterial Activities of a Bis-Chalcone Derived from Thiophene and Its Bis-Cyclized Products

Molecules

Abdullah M. Asiri¹ 

[1] ¹Chemistry Department, Faculty of Science, King Abdul Aziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia ²The Center of Excellence for Advanced Materials, King Abdul Aziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

关键词: chalcone;    pyrazoline;    pyrimidine;    anti-bacterial activity;    chloramphenicol;   

DOI  :  10.3390/molecules16010523

来源: mdpi

【 摘 要 】

A chalcone was prepared by the reaction of terephthalaldehyde with 3-acetyl-2,5-dimethylthiophene. Treatment of this chalcone with thiosemicarbazide/phenyl hydrazine/guanidine hydrochloride/thiourea afforded the corresponding pyrazoline,  pyrazole, and pyrimidine in good yields. All the new compounds have been characterized by IR, ¹H-NMR, ¹³C-NMR, GC-MS and elemental analyses. The anti-bacterial activity of these compounds were first tested in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the reference of standard drug chloramphenicol. The results showed that the pyrazoline derivative is better at inhibiting growth of both types of bacteria (Gram-positive and Gram-negative) compared to chloramphenicol.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.