Synthesis and biological activity of some new pyrazoline and pyrimidine derivatives

Journal of the Brazilian Chemical Society

Seham Y Hassan¹ 

[1] ,University of Alexandria Faculty of Science Department of ChemistryAlexandria,Egypt

关键词: chalcones;    pyrazoline;    pyrimidine;    antibacterial;    antifungal;   

DOI  :  10.1590/S0103-50532011000700014

来源: SciELO

【 摘 要 】

New series of pyrazoline 3-aryl-4,5-dihydro-1H-pyrazole-1-carbaldehydes (4-6), (aryl-4,5-dihydro-1H-pyrazol-1-yl)ethanones (9-11) and 3-aryl-4,5-dihydro-1H-pyrazoles (24 and 25) were synthesized by reacting chalcones (1-3) with hydrazine hydrate in either formic acid, acetic acid or ethanol, respectively. Also, new 6-arylpyrimidin-2-amine derivatives (32-34) were synthesized from the same chalcones. The structures of the newly synthesized compounds were established on the basis of IR, ¹H NMR, 13C NMR, mass spectral data and elemental analyses. The compounds were evaluated for their antibacterial and antifungal activities. Three heterocycles showed relevant activity against C. albicans and some compounds also showed activity against E. coli.

【 授权许可】

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