Palladium- and copper-catalyzed highly selective mono-coupling between 2,6-diiodoanisoles and terminal alkynes in the production of alkynylated anisoles as potential precursors of benzo[b]furans

Journal of the Brazilian Chemical Society

Allan F. C. Rossini²  Carlise Frota¹  Gleison A. Casagrande¹  Lucas Pizzuti¹  Cristiano Raminelli² 

[1] ,Universidade Federal de São Paulo Departamento de Ciências Exatas e da Terra Diadema SP ,Brazil

关键词: Sonogashira reaction;    selective mono-coupling;    alkynylated anisoles;    diiodinated benzo[b]furans;    palladium and copper catalysis;   

DOI  :  10.5935/0103-5053.20140200

来源: SciELO

【 摘 要 】

The coupling reaction between 2,6-diiodoanisoles and terminal alkynes using Pd(PPh3)2Cl2 and CuI as catalysts and diisopropylamine as base in toluene at room temperature for 12 h produced selectively alkynylated 2-iodoanisoles, in good to excellent yields (52-95%), which are useful building blocks with potential application in the synthesis of functionalized benzo[b]furans.

【 授权许可】

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