Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)-prop-1-yn-1-yl]phthalazines and Related Compounds

Molecules

Norbert Haider¹  Tamara Kabicher²  Johann Krbཬk² 

[1] id="af1-molecules-12-01900">Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Althanstraße 14, A-1090 Vienna, Austr

关键词: 1-[3-(indol-1-yl)prop-1-yn-1-yl]phthalazines;    N-propargylindoles;    palladium-catalyzed cross-coupling;    Sonogashira reaction;    antitumor activity;   

DOI  :  10.3390/12081900

来源: mdpi

【 摘 要 】

A series of novel 3-(indol-1-yl)prop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay.

【 授权许可】

Unknown   
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