Palladium- and copper-catalyzed highly selective mono-coupling between 2,6-diiodoanisoles and terminal alkynes in the production of alkynylated anisoles as potential precursors of benzo[b]furans

Journal of the Brazilian Chemical Society

Casagrande, Gleison A.¹  Pizzuti, Lucas¹  Raminelli, Cristiano¹  Universidade Federal da Grande Dourados, Dourados, Brazil¹  Rossini, Allan F. C.¹  Universidade Federal de São Paulo, Diadema, Brazil¹  Frota, Carlise¹ 

关键词: Sonogashira reaction;    selective mono-coupling;    alkynylated anisoles;    diiodinated benzo[b]furans;    palladium and copper catalysis;   

DOI  :  10.5935/0103-5053.20140200

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The coupling reaction between 2,6-diiodoanisoles and terminal alkynes using Pd(PPh3)2Cl2 and CuI as catalysts and diisopropylamine as base in toluene at room temperature for 12 h produced selectively alkynylated 2-iodoanisoles, in good to excellent yields (52-95%), which are useful building blocks with potential application in the synthesis of functionalized benzo[b]furans.

【 授权许可】

Unknown