Synthesis of quinolinediones by catalyst-free formal aza-[3+2+1] cycloaddition of enaminones, aldehydes and meldrum's acid

Journal of the Brazilian Chemical Society

Silvio Cunha¹  Lourenço L. B. De Santana¹ 

[1] ,Universidade Federal da Bahia Instituto Nacional de Ciência e Tecnologia Salvador BA ,Brazil

关键词: enaminones;    Meldrum's acid;    quinolinediones;    multicomponent reaction;   

DOI  :  10.5935/0103-5053.20140106

来源: SciELO

【 摘 要 】

A simple green synthesis of 4-aryl-tetrahydroquinoline-2,5-diones was developed, improving the three-component reaction of N-aryl substituted dimedone-based enaminones, aromatic aldehydes and Meldrum's acid. The method does not employ catalyst, heating or any special solvent or reaction condition, and has facile work-up and purification. Variations of enaminones and aldehydes substituents were somewhat tolerated.

【 授权许可】

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