Prenylated flavonoids from roots of Dahlstedtia glaziovii (Fabaceae)

Journal of the Brazilian Chemical Society

Edione F. Canzi²  Francisco A. Marques²  Sirlei D. Teixeira¹  Ana Maria G. A. Tozzi¹  Marcos J. Silva¹  Renata Maria T. Duarte¹  Marta Cristina T. Duarte¹  Ana Lúcia T. G. Ruiz¹  Paula A. Monteiro¹  João E. De Carvalho¹  Beatriz Helena L. N. Sales Maia² 

[1] ,Universidade Federal do Paraná Departamento de Química Curitiba PR ,Brazil

关键词: Lonchocarpus;    prenylated flavonoids;    dibenzoylmethane;    Dahlstedtia glaziovii;    antiproliferative activity;   

DOI  :  10.5935/0103-5053.20140071

来源: SciELO

【 摘 要 】

A phytochemical study of roots of Dahlstedtia glaziovii (Fabaceae) furnished a new dibenzoylmethane (glaziovione), along with eighteen known compounds. Their structures were determined through 1D and 2D nuclear magnetic resonance (NMR) (heteronuclear single quantum coherence, HSQC, and heteronuclear multiple bond correlation, HMBC) and high-resolution mass spectrometry (HRMS) spectral analyses. The antiproliferative activity was investigated for the crude extracts, the dibenzoylmethanes 2'-methoxy-8-(α-α-dimethylallyl)-furano-[4",5":3',4']-dibenzoylmethane, 3,4-methylenedioxy-2'-methoxy-8-(α-α-dimethylallyl)-furano-[4",5":3',4']-dibenzoylmethane and pongamol, and the flavones lanceolatin B, karanjin, pongapin and 3',4'-methylenedioxy-2",2"-dimethylpyrano-[5",6":8,7]-flavone. The dibenzoylmethanes were more active than the flavones.The extracts were evaluated for their antimicrobial effects, but none was shown to be active.

【 授权许可】

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