Prenylated flavonoids from roots of Dahlstedtia glaziovii (Fabaceae)

Journal of the Brazilian Chemical Society

Tozzi, Ana Maria G. A.¹  Ruiz, Ana Lúcia T. G.¹  Teixeira, Sirlei D.¹  Duarte, Marta Cristina T.¹  Monteiro, Paula A.¹  Maia, Beatriz Helena L. N. Sales¹  Universidade Federal de Goiás, Goiânia, Brazil¹  Universidade Tecnológica Federal do Paraná, Pato Branco, Brazil¹  Universidade Estadual de Campinas, Campinas, Brazil¹  Marques, Francisco A.¹  Duarte, Renata Maria T.¹  Canzi, Edione F.¹  Carvalho, João E. de¹  Silva, Marcos J.¹  Universidade Federal do Paraná, Curitiba, Brazil¹ 

关键词: Lonchocarpus;    prenylated flavonoids;    dibenzoylmethane;    Dahlstedtia glaziovii;    antiproliferative activity;   

DOI  :  10.5935/0103-5053.20140071

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A phytochemical study of roots of Dahlstedtia glaziovii (Fabaceae) furnished a new dibenzoylmethane (glaziovione), along with eighteen known compounds. Their structures were determined through 1D and 2D nuclear magnetic resonance (NMR) (heteronuclear single quantum coherence, HSQC, and heteronuclear multiple bond correlation, HMBC) and high-resolution mass spectrometry (HRMS) spectral analyses. The antiproliferative activity was investigated for the crude extracts, the dibenzoylmethanes 2'-methoxy-8-(α-α-dimethylallyl)-furano-[4",5":3',4']-dibenzoylmethane, 3,4-methylenedioxy-2'-methoxy-8-(α-α-dimethylallyl)-furano-[4",5":3',4']-dibenzoylmethane and pongamol, and the flavones lanceolatin B, karanjin, pongapin and 3',4'-methylenedioxy-2",2"-dimethylpyrano-[5",6":8,7]-flavone. The dibenzoylmethanes were more active than the flavones.The extracts were evaluated for their antimicrobial effects, but none was shown to be active.

【 授权许可】

Unknown