Enzymatic inhibition studies of selected flavonoids and chemosystematic significance of polymethoxylated flavonoids and quinoline alkaloids in Neoraputia (Rutaceae)

Journal of the Brazilian Chemical Society

Valéria R. De S. Moraes²  Daniela M. Tomazela²  Ricardo J. Ferracin²  Cleverson F. Garcia²  Míriam Sannomiya¹  M. Del Pilar C. Soriano¹  M. Fátima Das G. F. Da Silva²  Paulo C. Vieira²  João B. Fernandes²  Edson Rodrigues Filho²  Eva G. Magalhães¹  Aderbal F. Magalhães¹  Eli F. Pimenta¹  Dulce H. F. De Souza¹  Glaucius Oliva¹ 

[1] ,Universidade Federal de São Carlos Departamento de Química São Carlos SP ,Brazil

关键词: Rutaceae;    Leguminosae;    Neoraputia;    Murraya;    Citrus;    Lonchocarpus;    Trypanosoma cruzi;    alkaloid;    flavonoids;    chemosystematic;   

DOI  :  10.1590/S0103-50532003000300007

来源: SciELO

【 摘 要 】

Our taxonomic interest in the Neoraputia stimulated an investigation of N. paraensis searching for alkaloids. Fractions were monitored by ¹H NMR and ESI-MS/MS and only those which showed features of anthranilate alkaloids and flavonoids absent in the previous investigations were examined. Stems afforded the alkaloids flindersine, skimmianine, 8-methoxyflindersine and dictamnine; leaves yielded 3',4',7,8-tetramethoxy-5,6-(2",2"-dimethylpyrano)-flavone, 3',4',5,7,8-pentamethoxyflavone, 5-hydroxy-3',4',6,7-tetramethoxyflavone, 3',4'-methylenedioxy-5,6,7-trimethoxyflavone and 5-hydroxy-3',4'-methylenedioxy-6,7-dimethoxyflavone. The alkaloids have remained undiscovered for 10 years. A number of flavonoids isolated from N. paraensis, N. magnifica, Murraya paniculata, Citrus sinensis graft (Rutaceae), Lonchocarpus montanus (Leguminosae) were evaluated for their ability to inhibit the enzymatic activity of the protein glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi. Highly oxygenated flavones and isoflavone were the most actives.

【 授权许可】

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