Tribromoisocyanuric acid/triphenylphosphine: a new system for conversion of alcohols into alkyl bromides

Journal of the Brazilian Chemical Society

Vitor S. C. De Andrade¹  Marcio C. S. De Mattos¹ 

[1] ,Universidade Federal do Rio de Janeiro Instituto de Química Departamento de Química OrgânicaRio de Janeiro RJ ,Brazil

关键词: alcohols;    alkyl bromides;    tribromoisocyanuric acid;    triphenylphosphine;   

DOI  :  10.5935/0103-5053.20140055

来源: SciELO

【 摘 要 】

An efficient and facile method has been developed for the conversion of alcohols into alkyl bromides under neutral conditions using tribromoisocyanuric acid and triphenylphosphine (molar ratio 1.0:0.7:2.0, alcohol/tribromoisocyanuric acid/triphenylphosphine) in dichloromethane at room temperature. This method can be applied for the conversion of primary, secondary, benzylic and allylic alcohols, and their corresponding bromides are obtained in 67-82 % yield. Tertiary alcohols do not react under these conditions.

【 授权许可】

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