Appel Reaction of Carboxylic Acids with Tribromoisocyanuric Acid/Triphenylphosphine: a Mild and Acid-Free Preparation of Esters and Amides

Journal of the Brazilian Chemical Society

Mattos, Marcio C. S. de¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil¹  Sindra, Haryadylla da Cunha¹ 

关键词:  amides;    esters;    tribromoisocyanuric acid;    acylation;    triphenylphosphine;   

DOI  :  10.5935/0103-5053.20160006

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A facile and efficient method for esterification and amidation of carboxylic acids under neutral conditions has been developed. Esters and amides can be prepared by reacting a carboxylic acid (1 mmol) with tribromoisocyanuric acid (0.37 mmol) and triphenylphosphine (1 mmol) in dichloromethane at room temperature, followed by addition of an alcohol or an amine, respectively.

【 授权许可】

Unknown