Flavonoid glycosides from Hosta longipes, their inhibition on NO production, and nerve growth factor inductive effects

Journal of the Brazilian Chemical Society

Chung Sub Kim²  Oh Wook Kwon¹  Sun Yeou Kim¹  Kang Ro Lee² 

[1] ,Sungkyunkwan University School of Pharmacy Natural Products LaboratorySuwon,Republic of Korea

关键词: Hosta longipes;    flavonoid glycoside;    nitric oxide;    nerve growth factor;   

DOI  :  10.5935/0103-5053.20140060

来源: SciELO

【 摘 要 】

An extended phytochemical investigation of the leaves of Hosta longipes identified the new flavonoid glycoside, kaempferol-3-O-β-D-glucopyranosyl-(1→2)-[6"'-O-acetyl-β-D-glucopyranoside]-7-O-β-D-glucopyranoside and five known flavonoid derivatives. The structures of two compounds were revealed by extensive NMR methods (¹H and 13C NMR, ¹H-¹H COSY, HMQC and HMBC) and chemical hydrolysis. NMR data of one of them are published for the first time. Bioactivities of six compounds revealed that five strongly inhibited the production of nitric oxide (NO) with IC50 values of 11.56-15.97 µm in lipopolysaccharide (LPS)-stimulated BV-2 cells without cell toxicity. Two compounds showed moderate induction of secretion of nerve growth factor (NGF) in C6 glioma cells (124.70 ± 7.71% and 117.02 ± 3.60%, respectively).

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