Flavonoid glycosides from Hosta longipes, their inhibition on NO production, and nerve growth factor inductive effects

Journal of the Brazilian Chemical Society

Kim, Sun Yeou¹  Kim, Chung Sub¹  Kyung Hee University Global Campus, Yongin, Republic of Korea¹  Gachon Medical Research Institute, Incheon, Republic of Korea¹  Sungkyunkwan University, Suwon, Republic of Korea¹  Kwon, Oh Wook¹  Gachon University, Incheon, Republic of Korea¹  Lee, Kang Ro¹ 

关键词: Hosta longipes;    flavonoid glycoside;    nitric oxide;    nerve growth factor;   

DOI  :  10.5935/0103-5053.20140060

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

An extended phytochemical investigation of the leaves of Hosta longipes identified the new flavonoid glycoside, kaempferol-3-O-β-D-glucopyranosyl-(1→2)-[6"'-O-acetyl-β-D-glucopyranoside]-7-O-β-D-glucopyranoside and five known flavonoid derivatives. The structures of two compounds were revealed by extensive NMR methods (1H and 13C NMR, 1H-1H COSY, HMQC and HMBC) and chemical hydrolysis. NMR data of one of them are published for the first time. Bioactivities of six compounds revealed that five strongly inhibited the production of nitric oxide (NO) with IC50 values of 11.56-15.97 µm in lipopolysaccharide (LPS)-stimulated BV-2 cells without cell toxicity. Two compounds showed moderate induction of secretion of nerve growth factor (NGF) in C6 glioma cells (124.70 ± 7.71% and 117.02 ± 3.60%, respectively).

【 授权许可】

Unknown