Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis

Journal of the Brazilian Chemical Society

Ana Paula De Lima¹  Jessica S. Stefano¹  Rodrigo H. O. Montes¹  Rafael R. Cunha¹  Luiz A. J. Silva¹  Eduardo M. Richter¹  Rodrigo A. A. Muñoz¹ 

[1] ,Universidade Federal de Uberlândia Instituto de Química Uberlândia MG ,Brazil

关键词: chlorhexidine oxidation;    bare electrode;    organochloride;    antiseptic;   

DOI  :  10.5935/0103-5053.20130267

来源: SciELO

【 摘 要 】

The electrochemical oxidation of chlorhexidine is investigated for the first time and its amperometric determination using a flow-injection analysis (FIA) system is demonstrated. An oxidation peak was observed at around 1.3 V in a 0.1 mol L-1 HClO4 solution at a glassy-carbon electrode. The mechanism of the electrochemical oxidation of chlorhexidine is pH-dependent and involves a single-electron transfer possibly via radical cation formation. The FIA parameters were optimized and a detection limit of 0.3 µmol L-1 was obtained. The proposed method was applied in mouth rinses and skin disinfectants samples and compared with high-performance liquid chromatography.

【 授权许可】

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