Electrochemical oxidation of chlorhexidine and its amperometric determination by flow-injection analysis

Journal of the Brazilian Chemical Society

Richter, Eduardo M.¹  Montes, Rodrigo H. O.¹  Lima, Ana Paula de¹  Silva, Luiz A. J.¹  Muñoz, Rodrigo A. A.¹  Stefano, Jessica S.¹  Cunha, Rafael R.¹  Universidade Federal de Uberlândia, Uberlândia, Brazil¹ 

关键词: chlorhexidine oxidation;    bare electrode;    organochloride;    antiseptic;   

DOI  :  10.5935/0103-5053.20130267

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

The electrochemical oxidation of chlorhexidine is investigated for the first time and its amperometric determination using a flow-injection analysis (FIA) system is demonstrated. An oxidation peak was observed at around 1.3 V in a 0.1 mol L-1 HClO4 solution at a glassy-carbon electrode. The mechanism of the electrochemical oxidation of chlorhexidine is pH-dependent and involves a single-electron transfer possibly via radical cation formation. The FIA parameters were optimized and a detection limit of 0.3 µmol L-1 was obtained. The proposed method was applied in mouth rinses and skin disinfectants samples and compared with high-performance liquid chromatography.

【 授权许可】

Unknown