Solvent-free catalysed synthesis of tetrahydropyran odorants: the role of SiO

Journal of the Brazilian Chemical Society

Alexandra Macedo²  Edison P. Wendler²  Alcindo A. Dos Santos¹  Julio Zukerman-schpector²  Edward R. T. Tiekink¹ 

[1] ,Universidade Federal de São Carlos Departamento de Química São Carlos SP ,Brazil

关键词: Prins-cyclisation;    solvent-free catalysis;    green chemistry;    tetrahydropyrans;    fragrances;   

DOI  :  10.1590/S0103-50532010000800023

来源: SciELO

【 摘 要 】

An efficient, green and solvent-free catalysed Prins-cyclization reaction based on the simple grinding of an aldehyde and a homoallylic alcohol in the presence of catalytic amount of p-TSA on silica gel is reported. By this protocol were synthesized tetrahydropyran odorants including commercial Florol® and Clarycet®, in one and two steps respectively.

【 授权许可】

CC BY   
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