The prins cyclization reaction: an efficient stractegy for the stereoselective synthesis of substituted tetrahydropyran rings

Química Nova

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil¹  Vasconcellos, Mário Luiz A. A.¹  Miranda, Leandro S. M.¹  Universidade Federal da Paraíba, oão Pessoa, Brasil¹ 

关键词: Prins cyclization;    tetrahydropyrans;    stereoselective synthesis.;   

DOI  :  10.1590/S0100-40422006000400035

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The Prins cyclization reaction has significantly advanced in the last years as demonstrated by a number of applications described in the literature. The objective of this report is to introduce this powerful synthetic methodology to the undergraduate and graduated student, since it is rarely presented in an organic synthesis formal course. This reaction is, in some cases, the methodology of choice for the preparation of natural products or drugs that present the tetrahydropyrane moiety in their structures. In this report we show some aspects of this reaction, including mechanism, scope and limitations.

【 授权许可】

Unknown