A reação de ciclização de prins: uma estratégia eficiente para síntese estereosseletiva de anéis tetraidropirânicos substituídos

Química Nova

Mário Luiz A. A. Vasconcellos²  Leandro S. M. Miranda¹ 

[1],Universidade Federal da Paraíba Departamento de Química oão Pessoa PB ,Brasil

关键词: Prins cyclization;    tetrahydropyrans;    stereoselective synthesis;   

DOI  :  10.1590/S0100-40422006000400035

来源: SciELO

【 摘 要 】

The Prins cyclization reaction has significantly advanced in the last years as demonstrated by a number of applications described in the literature. The objective of this report is to introduce this powerful synthetic methodology to the undergraduate and graduated student, since it is rarely presented in an organic synthesis formal course. This reaction is, in some cases, the methodology of choice for the preparation of natural products or drugs that present the tetrahydropyrane moiety in their structures. In this report we show some aspects of this reaction, including mechanism, scope and limitations.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License