The prins cyclization reaction: an efficient stractegy for the stereoselective synthesis of substituted tetrahydropyran rings

Quimica nova

Vasconcellos, Mário Luiz A. A.¹  Miranda, Leandro S. M.² 

[1] Universidade Federal da Paraíba, oão Pessoa, Brasil;Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

关键词: Prins cyclization;    tetrahydropyrans;    stereoselective synthesis.;   

DOI  :  10.1590/S0100-40422006000400035

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The Prins cyclizationreaction has significantly advanced in the last years as demonstrated by a numberof applications described in the literature. The objective of this report isto introduce this powerful synthetic methodology to the undergraduate and graduatedstudent, since it is rarely presented in an organic synthesis formal course.This reaction is, in some cases, the methodology of choice for the preparationof natural products or drugs that present the tetrahydropyrane moiety in theirstructures. In this report we show some aspects of this reaction, includingmechanism, scope and limitations.

【 授权许可】

CC BY