Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones

Journal of the Brazilian Chemical Society

Gizelle A. B. Vieira¹  Daniel M. De Freitas Araujo¹  Telma L. G. Lemos¹  Marcos Carlos De Mattos¹  Maria Da Conceição F. De Oliveira¹  Vânia M. M. Melo¹  Gonzalo De Gonzalo²  Vicente Gotor-fernández²  Vicente Gotor² 

[1] ,Universidade Federal do Ceará Departamento de Química Orgânica e Inorgânica Fortaleza CE ,Brazil

关键词: alcohol dehydrogenases;    biocatalysis;    Candida tropicalis;    ketones;    yeast;   

DOI  :  10.1590/S0103-50532010000800015

来源: SciELO

【 摘 要 】

The reactivity and stereoselectivity showed by a new strain of Candida tropicalis in the reduction of prochiral ketones have been compared with the ones previously attained in our laboratory using microorganisms from the Brazilian biodiversity. In this manner, Candida tropicalis has demonstrated its versatility as stereoselective agent in the bioreduction of a series of aromatic ketones. These prochiral compounds were converted into their corresponding optically alcohols with moderate to excellent stereopreference depending on the substrate structure. Among ketones tested, nitroacetophenones were enzymatically reduced to enantiopure (S)-alcohol with complete conversion.

【 授权许可】

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