期刊论文详细信息
Journal of the Brazilian Chemical Society
Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones
Gonzalo, Gonzalo de1  Vieira, Gizelle A. B.1  Lemos, Telma L. G.1  Araujo, Daniel M. de Freitas1  Universidade Federal do Ceará, Fortaleza, Brazil1  Gotor, Vicente1  Oliveira, Maria da Conceição F. de1  Universidad de Oviedo, Oviedo, Spain1  Mattos, Marcos Carlos de1  Melo, Vânia M. M.1  Gotor-Fernández, Vicente1 
关键词: alcohol dehydrogenases;    biocatalysis;    Candida tropicalis;    ketones;    yeast;   
DOI  :  10.1590/S0103-50532010000800015
学科分类:化学(综合)
来源: SciELO
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【 摘 要 】

The reactivity and stereoselectivity showed by a new strain of Candida tropicalis in the reduction of prochiral ketones have been compared with the ones previously attained in our laboratory using microorganisms from the Brazilian biodiversity. In this manner, Candida tropicalis has demonstrated its versatility as stereoselective agent in the bioreduction of a series of aromatic ketones. These prochiral compounds were converted into their corresponding optically alcohols with moderate to excellent stereopreference depending on the substrate structure. Among ketones tested, nitroacetophenones were enzymatically reduced to enantiopure (S)-alcohol with complete conversion.

【 授权许可】

Unknown   

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