期刊论文详细信息
Journal of the Brazilian Chemical Society | |
Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives | |
Cecilia M. Scorzo2  Mirta L. Fascio2  Norma B. D'accorso2  Margarita Gutiérrez Cabrera1  Luís Astudillo Saavedra1  | |
[1] ,Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales Departamento de Química OrgánicaBuenos Aires,Argentina | |
关键词: D-glyceraldehyde; heterocyclic compounds; cycloaddition; acetylcholinesterase; Alzheimer´s disease; | |
DOI : 10.1590/S0103-50532010000100008 | |
来源: SciELO | |
【 摘 要 】
We report herein the convenient procedures for the syntheses of different heterocyclic compounds from 2,3-O-isopropylidene-D-glyceraldehyde using intramolecular cyclization, 1,3-dipolar cycloaddition or bimolecular coupling reactions. The products were characterized by ¹H and 13C NMR spectroscopy and elemental analysis. The new heterocycles and their derivatives were evaluated as inhibitors of acetylcholinesterase enzyme.
【 授权许可】
CC BY
All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License
【 预 览 】
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