Synthesis and antiacetylcholinesterase activity of new D-glyceraldehyde heterocyclic derivatives

Journal of the Brazilian Chemical Society

Cecilia M. Scorzo²  Mirta L. Fascio²  Norma B. D'accorso²  Margarita Gutiérrez Cabrera¹  Luís Astudillo Saavedra¹ 

[1] ,Universidad de Buenos Aires Facultad de Ciencias Exactas y Naturales Departamento de Química OrgánicaBuenos Aires,Argentina

关键词: D-glyceraldehyde;    heterocyclic compounds;    cycloaddition;    acetylcholinesterase;    Alzheimer´s disease;   

DOI  :  10.1590/S0103-50532010000100008

来源: SciELO

【 摘 要 】

We report herein the convenient procedures for the syntheses of different heterocyclic compounds from 2,3-O-isopropylidene-D-glyceraldehyde using intramolecular cyclization, 1,3-dipolar cycloaddition or bimolecular coupling reactions. The products were characterized by ¹H and 13C NMR spectroscopy and elemental analysis. The new heterocycles and their derivatives were evaluated as inhibitors of acetylcholinesterase enzyme.

【 授权许可】

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