Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system

Journal of the Brazilian Chemical Society

Marieta L. C. Passos²  M. Lúcia M. F. S. Saraiva²  José L. F. C. Lima²  M. Graças A. Korn¹ 

[1] ,Universidade do Porto Faculdade de Farmácia Serviço de Química-FísicaPorto,Portugal

关键词: beta-blockers;    sequential injection analysis;    SIA;    spectrophotometry;    pharmaceutical formulations;   

DOI  :  10.1590/S0103-50532008000300027

来源: SciELO

【 摘 要 】

A mechanized system for the determination of beta-blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.

【 授权许可】

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