Determination of metoprolol, acebutolol and propranolol in pharmaceutical formulations using the same SIA system

Journal of the Brazilian Chemical Society

Korn, M. Graças A.¹  Saraiva, M. Lúcia M. F. S.¹  Passos, Marieta L. C.¹  Universidade Federal da Bahia, Salvador, Brazil¹  Lima, José L. F. C.¹  Universidade do Porto, Porto, Portugal¹ 

关键词: beta-blockers;    sequential injection analysis;    SIA;    spectrophotometry;    pharmaceutical formulations;   

DOI  :  10.1590/S0103-50532008000300027

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

A mechanized system for the determination of b–blockers in pharmaceutical formulations is presented. Using the Sequential Injection Analysis (SIA) technique it was achieved a simple, economical and versatile methodology adaptable to any pharmaceutical control involving these substances. It does not require any pre-treatment for the samples, as they must only be dissolved in acid before analysis. Linear calibration plots were obtained for metoprolol (40.52 - 250 mg L-1), acebutolol (32.85 - 140 mg L-1) and propranolol (16.58 - 120 mg L-1). A R.S.D. lower than 5% was attained. The methodology was used in tablets, injections and prolonged-release capsules. Common excipients used in pharmaceuticals do not interfere. Statistical comparison of the results obtained with the proposed methodology and with the official methods showed good agreement (95% confidence level). SIA system produces only 2.50 mL of effluents per determination whereas the reference methodologies consume around 140 mL.

【 授权许可】

Unknown