Sequential injection analysis system with spectrophotometric detection for determination of norfloxacin and ciprofloxacin in pharmaceutical formulations

Química Nova

José Luiz Rufino²  Helena Redigolo Pezza²  Leonardo Pezza²  Paula C. A. G. Pinto¹  M. Lúcia M. F. S. Saraiva¹  José L. F. C. Lima¹ 

[1] ,Universidade Estadual de São Paulo Instituto de Química de Araraquara Araraquara SP ,Brasil

关键词: sequential injection analysis;    spectrophotometry;    pharmaceutical formulations;   

DOI  :  10.1590/S0100-40422011000200016

来源: SciELO

【 摘 要 】

This work proposes a sequential injection analysis (SIA) system for the spectrophotometric determination of norfloxacin (NOR) and ciprofloxacin (CIP) in pharmaceutical formulations. The methodology was based on the reaction of these drugs with p-(dimethylamino)cinnamaldehyde in micellar medium, producing orange colored products (λmax = 495 nm). Beer´s law was obeyed in the concentration range from 2.75x10-5 to 3.44x10-4 mol L-1 and 3.26x10-5 to 3.54x10-4 mol L-1 for NOR and CIP, respectively and sampling rate was 25 h-1. Commercial samples were analyzed and results obtained through the proposed method were in good agreement with those obtained using the reference procedure for a 95% confidence level.

【 授权许可】

CC BY-NC   
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