Chemoselective synthesis of novel thiatriazolophanes

Journal of the Brazilian Chemical Society

Madhukar S. Chande¹  Kiran A. Puthamane¹  Pravin A. Barve¹  Rahul R. Khanwelkar¹  Deepak S. Venkataraman¹ 

[1] ,The Institute of Science Department of Chemistry Mumbai,India

关键词: 4-alkyl/aryl-5-thia-1;    2;    4-triazoles;    1;    omega-dihaloalkanes;    N-alkyl/aryl thiatriazolophanes;    chemoselectivity;   

DOI  :  10.1590/S0103-50532008000100008

来源: SciELO

【 摘 要 】

Bis-[4-alkyl/aryl-5-thia-1,2,4-triazoles] were prepared by fusion of diacids and thiosemicarbazides by condensation of aromatic acid hydrazides with isothiocyanate. Chemoselective alkylation of these bis-[4-alkyl/aryl-5-thia-1,2,4-triazoles] with 1,omega-dihaloalkanes in presence of potassium hydroxide in aqueous methanol afforded novel N-alkyl/aryl thiatriazolophanes.

【 授权许可】

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